What induction regimen do you choose for high risk newly diagnosed multiple myeloma in light of the recent high risk focused studies?

Two things are clear from the slew of high-risk enrichment studies and subgroup analyses that have been done.

1. In the age of upfront quadruplet therapy with an anti-CD38 monoclonal antibody, outcomes for patients with one high-risk cytogenetic abnormality are very good, even in the absence of prolong...

It's probably not the induction that's interesting since the majority of high risk patients respond to most 3-4 drug cocktails.

What about Dara-KRd followed by transplant then Dara-KP maintenance?

Since no consolidation or CART in the second line, this might be the most active combination for now.

I agree with @Dr. First Last on all fronts! I have no doubt that @Dr. First Last is referring to the flurry of new studies that were either presented at IMS last week and/or published. For example:

1. The final MASTER trial results of Dara-KRd plus transplant led by Dr. Costa and colleagues (not specif...

Would go with Dara KRD followed by double auto SCT and dara and len maintenace as in IFM 2018-04 study. Not sure if Isa KRD + double transplant as in GMMG concept is any better.