What is optimal timing or sequencing of therapy for patients with synchronous locally advanced triple negative breast cancer and ovarian cancer with peritoneal carcinomatosis?
Answer from: Medical Oncologist at Academic Institution
Because delays in surgical healing can affect initiation of chemotherapy in ovarian cancer, I would consider neoadjuvant therapy for both the ovarian and breast cancer. Alternatively, one could do debunking surgery and then chemotherapy. I would recommend carboplatin q 3 weeks with taxol weekly x 6 ...
Sign in or Register to read more
Answer from: Medical Oncologist at Community Practice
I agree with the chemotherapy, but I would never delay therapy for a locally advanced triple negative cancer. I would do neoadjuvant therapy and surgery later.
Genetic testing is critical here and the patient has a high chance of HRD-related mutation and consideration of a PARP inhibitor foll...