What is the best way to manage low systolic blood pressures on clozapine when the patient has failed multiple other antipsychotic trials?

Orthostatic hypotension is considered a common side effect during clozapine titration, specifically due to its alpha-1 receptor antagonism. This effect is most commonly seen when initiating clozapine or with dose increases.

General initial strategies to address this side effect include reevaluating t...