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What is the choice of treatment for a teenager with low risk neuroblastoma s/p resection?

Observe versus adjuvant chemotherapy?
1 Answer
Mednet MemberInvited Expert
Pediatric Hematology/Oncology · Vanderbilt University Medical Center
Answered on

According to the Revised Neuroblastoma Risk Classification (Irwin et al., PMID 34319759), age is not a factor in determining whether someone is low risk. So if this child has been determined to have low-risk neuroblastoma, they have/had an L1 tumor, either without MYCN amplification, or with MYCN amplification if the patient underwent gross total resection. Currently, recommended treatment of low-risk neuroblastoma is surgical resection, without adjuvant chemotherapy or radiation therapy.

COG study P9641 demonstrated excellent outcomes for patients with low-risk neuroblastoma with surgery alone. While that study used different staging (INSS stage 1, 2a, 2b, 4s) rather than INRG staging (with L1 and MS being the only groups that can be low-ri...

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