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What is the clinical significance of a low titer RNP, negative Sm, but Sm/RNP that is very high titer?
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Mednet Member
Rheumatology · Uniformed Services University of the Health Sciences (USUHS)
Important question as I've seen clinicians incorrectly interpret anti-Sm-RNP as anti-Smith antibody.
The different autoantibodies (RNP, Smith, Sm/RNP) react to different antigens as follows:
- Anti-RNP can react to multiple components (antigens) of the U1 small nuclear RNP particle (snRNP),
- Anti-Smith ...