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What is the clinical utility of getting repeat antibody testing in patients with recurrent symptoms and a history of Miller-Fischer syndrome?

The patient returned with recurrent subjective sensory or motor deficits. The initial GQ1B was >1:6400. Two years later, GQ1B was 1:3200.
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Should we empirically treat patients with recurrent symptoms of Miller-Fischer Syndrome?

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2 Answers
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Mednet MemberInvited Expert
Neurology · Cedars-Sinai Medical Center
Answered on

The treatment of MFS is controversial and not addressed in the recently published guidelines. Should a patient exhibit muscle weakness beyond facial and EOM, it could imply an overlap between MFS and/or GBS. While there's limited study in this area, persistent antibodies, albeit reduced, might not s...

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Mednet Member
Mednet MemberInvited Expert
Neurology · University of Minnesota
Answered on

Recurrence of Miller-Fisher syndrome is exceptionally rare, and I only became aware of this possibility until I retrieved some relevant literature. Given its extreme rarity, and noting that the documented recurrences were primarily identified based on clinical features rather than antibody measureme...

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