What is the incidence of melanoma arising from vitiliginous patches, and do they develop from different mechanisms than melanomas arising from normal skin?

The exact incidence of melanoma arising within established vitiligo lesions has not been well defined.

Generally, patients with vitiligo develop melanoma (as well as non-melanoma skin cancers) in the areas of their normal skin compared to their de-pigmented lesions [1, 11].

That being said, there are...