What is the most appropriate adjuvant treatment for a GBM in a young patient <50 with a poor performance status (ECOG 3-4)?
Would you offer a hypofractionated course of RT? Does the extent of resection or MGMT status influence your decision? What factors do you consider when making this treatment decision?
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What is your preferred postoperative treatment approach for a patient <50 with newly diagnosed GBM and ECOG 3-4?
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1 Answer
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Radiation Oncology · Columbia University Irving Medical Center
Answered on
In general, for a young patient with poor performance status, I would like to know whether the poor performance status is potentially reversible, such as from edema, mass effect, seizures, hydrocephalus, or a recovering post-op deficit, versus fixed or disease-driven. If performance status improves,...
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