What is the optimal age at which a patient with sickle cell disease should undergo allogeneic stem cell transplant?

Ideally, would be at diagnosis to limit sickle related injury and generally, younger patients have less complications but since curative treatment is not perfect, it depends mainly on the donor. For matched sibling donor transplant, under age 5yrs has best outcomes with over 15yrs having more GVHD a...

This question is challenging to answer. The long-term outcomes of transplant vs. disease modifying treatment have never been rigorously compared. Also, more data is needed on the outcomes of reduced intensity transplantation and for those undergoing transplant with "less" severe SCD in childhood to ...