Topics:
Hematologic Malignancies • Medical Oncology • Myeloma • NCI-CCC Tumor Board Question • UCSF • NCI-CCC Myeloma Tumor Board Question
What is the optimal prophylaxis regimen to use prior to a selinexor based regimen in the treatment of multiple myeloma for nausea and electrolyte abnormalities?
Answer from: Medical Oncologist at Community Practice
The official Karyopharm guidelines for nausea are as follows: NK-1R antagonist OR a combination of 5-HT3 antagonist AND olanzapine. So the details are:a) All patients should receive ondansetron 8 mg or equivalent, unless contraindicated, orally 1 hour before each dose of selinexor and q 8 hours for ...
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Answer from: Medical Oncologist at Academic Institution
A once-weekly (as opposed to twice-weekly) selinexor dosing will surely help to cut down on side effects, especially nausea and vomiting. It's also important to educate patients thoroughly that even though it is a pill, it is still once a week and not daily (unlike lenalidomide for example), and sho...
Comments
Medical Oncologist at University of Washington, Fred Hutchinson Cancer Research Center
Agreed on all fronts! And once-weekly clinic visit...
Agreed on all fronts! And once-weekly clinic visit...
Medical Oncologist at University of Chicago
First month, I like to check on them once a week o...
First month, I like to check on them once a week o...