What is the radiation volume for M+ pure germinoma with brain only extra-ventricular mets and negative CSF/spine imaging?
Is chemotherapy recommended for M+ germinoma?
CR to chemo; Spine MRI negative; CSF negative
Is CSI required or whole brain radiation is sufficient for the initial phase?
What doses should be employed for each phase?
1 Answer
Mednet Member
Radiation Oncology · St Jude Children's Research Hospital
Answered on · Updated on
In general, I wouldn't recommend chemo for M+ Germinoma kids because it does not favorably improve the therapeutic ratio based on the findings from GCT96 (NCT00293358).
Independent of chemo, 24 Gy CSI with a boost to 36-40Gy is sufficient for cure.
With chemo, 21 Gy CSI & an involved field boost to 3...
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