What is the role for TTFields in patients who cannot undergo complete surgical resection for glioblastoma?
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What treatment do you recommend for patients with glioblastoma and a good PS who cannot undergo complete surgical resection?
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2 Answers
Mednet MemberInvited Expert
Radiation Oncology · Florida International University
Answered on
A gross total resection is not a requirement for the use of TTF, and therefore these patients can be evaluated for this therapeutic option.
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Radiation Oncology · Columbia University Irving Medical Center
Answered on
The EF14 trial included newly diagnosed glioblastoma patients who had gross total resections and those who had biopsies. Only 54% of patients had a GTR and 13% had biopsy. TTF plus temzolomide was associated with an increase in PFS and OS in all subgroups including extent of resection. So even if gr...
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