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What is the role of adjuvant radiation therapy for stage III melanoma in the era of adjuvant Opdivo?
Burnmeister data from 2012 showed a local control benefit for radiation therapy in selected patients, but that was without immunotherapy. What specific clinico-pathologic factors (e.g., number of nodes, desmoplastic histology, primary site) guide your decision to recommending the addition of RT to standard-of-care immunotherapy, and how would you sequence therapy?
Answer from: Radiation Oncologist at Academic Institution
In this era of immunotherapy for clinical stage 3 melanoma, the role of postoperative nodal basin RT, once considered nearly standard, appears to be waning. A relatively recent single institutional retrospective (lots of problems I realize) Canadian series (Kibel et al., PMID 38136412) reviewed thei...
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Radiation Oncologist at University of Missouri at Columbia, Ellis Fischel Cancer Cener
interesting article. but it compared RT alone to S...
interesting article. but it compared RT alone to S...
Radiation Oncologist at West Virginia University
I don't disagree with you about the likely benefit...
I don't disagree with you about the likely benefit...
Answer from: Radiation Oncologist at Academic Institution
Under most circumstances, I recommend the use of postoperative radiation therapy for all but the smallest widely excised lesions. In my experience, and borne out by the literature, the use of postoperative radiation therapy with most malignancies, melanoma included, shows definite survival benefits....
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Radiation Oncologist at Northeast Alabama Regional Medical Center
I just came here to say @Carl R. Bogardus was...
I just came here to say @Carl R. Bogardus was...
Radiation Oncologist at Yale School of Medicine
Agree whole heartedly. We sent flowers to his fami...
Agree whole heartedly. We sent flowers to his fami...
I agree that the role of adjuvant radiation is unc...
There is no singular policy that we uniformly adhe...
What is your adjuvant dose and fractionation for r...