What is the role of splenectomy versus systemic therapy in splenic marginal zone lymphoma?

With the introduction of rituximab and other CD20 monoclonals, the role of splenectomy in splenic marginal zone lymphoma is shrinking. There are rare clinical scenarios where I would still recommend splenectomy in splenic marginal zone lymphoma; huge splenomegaly with disabling symptoms, splenic tra...

The type of splenic lymphoma may have to be taken into consideration as splenic lymphomas can range from indolent diseases like splenic marginal zone lymphoma and follicular lymphoma to aggressive entities like diffuse large B cell lymphoma or hepatosplenic T-cell lymphoma.

Historically, splenectomy ...