What is the significance of isolated increase of Asialo-GM1 antibodies with nerve conduction suggestive of sensory motor axonal polyneuropathy?

These autoantibodies need to be interpreted with clinical context.

Generally, GM1 IgM antibodies are associated with multifocal motor neuropathy with conduction block (MMN), which is a pure motor syndrome with acquired demyelinating features on nerve conductions/EMG.

GM1 IgG antibodies are typically...