What is the target ferritin level for patients with hereditary hemochromatosis and signs of end-organ damage?

Topics: Pediatric Oncology • Hematology • Pediatric Hematology • Benign Hematology • Iron Homeostasis

For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?

Answer from: at Academic Institution

I believe the best marker to guide phlebotomy therapy for iron overload is the serum ferritin concentration. I use a target ferritin level of approximately 50 ng/ml. However, one could justify a ferritin level of <200 ng/ml from the literature of serum ferritin compared to body iron stores in HFE...

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Medical Oncologist at Sweetwater Regional Medical Center
What about in patients who have a concurrent illne...

Answer from: at Academic Institution

Treatment should be initiated in C282Y homozygotes with an elevated SF, defined as >300 ng/mL in men and >200 ng/mL in women, along with a TS of ≥ 45%.Phlebotomy should be done weekly with monitoring serum ferritin every 4 weeks till serum ferritin is <200 ng/ml.Then continue weekly phle...

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