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Topics:
Allergy & Immunology • Mast Cell Disorders
What is the utility of remibrutinib or other tyrosine kinase inhibitors in MCAS?
Answer from: at Community Practice
MCAS can be due to clonal (mastocytosis) or non-clonal (IgE and non-IgE mediated mast cell activation or idiopathic) etiologies. Remibrutinib is a btk inhibitor, currently only approved for chronic spontaneous urticaria, but not for MCAS. Btk is involved in IgE receptor signal transduction. In patie...
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