What is your approach to a situation where DILI is suspected secondary to an important medication (e.g., anticoagulation, antibiotics, etc.), but the diagnosis is uncertain and the liver injury is relatively mild?

If the drug suspected to induce liver injury causes symptoms and ALT is >3 times the upper limit of normal (ULN), I would stop the drug and find an alternative. Even if no symptoms are present, I would stop if ALT is >5 times ULN. Any level increase of ALT below the above parameters would still requ...

When DILI is suspected but the diagnosis is not clear and the liver injury is mild I generally take a cautious and individualized approach. review the timing of medication exposure assess for alternative causes of liver enzyme abnormalitie and monitor liver tests closely if the medication is clinica...