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General Internal Medicine • Hematology • Infectious Disease • Hepatology • Hospital Medicine • Primary Care • General Primary Care • General Hospital Medicine
What is your approach to a situation where DILI is suspected secondary to an important medication (e.g., anticoagulation, antibiotics, etc.), but the diagnosis is uncertain and the liver injury is relatively mild?
Are there situations in which you would continue the possible offending agent with close monitoring?
Answer from: at Academic Institution
If the drug suspected to induce liver injury causes symptoms and ALT is >3 times the upper limit of normal (ULN), I would stop the drug and find an alternative. Even if no symptoms are present, I would stop if ALT is >5 times ULN. Any level increase of ALT below the above parameters would stil...
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