What is your approach to adjuvant treatment of surgically staged, deeply invasive grade 3 endometrioid endometrial cancer with no lymph node involvement?

It depends on p53 and LVSI status. If wild-type and no LVSI, I would recommend discussion with radiation oncology regarding VBT vs EBRT. If aberrant p53, I treat as uterine serous (chemotherapy with vaginal brachy or EBRT), and with extensive LVSI, I would recommend EBRT, chemotherapy, or CRT.