What is your approach to exit-site prophylaxis in patients receiving peritoneal dialysis who are unable to tolerate gentamicin or mupirocin due to allergic reactions?

There are a number of other antibacterial regimens that have been proposed, most of which are either ineffective or actually pose a higher risk of fungal infections (at least in diabetic patients). These include polysporin triple antibiotic ointment and medical-grade antibacterial honey. The only agent I am aware of that may effectively substitute for mupirocin or gentamicin- and my "n of one" experience is favorable- is ciprofloxacin otologic solution (Montenegro et al., PMID 10809245).