What is your approach to further work-up and management of neutropenia in patients with SLE/RA overlap?
For example, a patient with a bone marrow biopsy that shows normocellular bone marrow. Prior management with leflunomide and HCQ with neutropenia attributed to drug effect; however, lack of improvement following medication discontinuation.
2 Answers
Mednet MemberInvited Expert
Rheumatology · Mobile Medical Care Inc
Answered on
This is an interesting situation that comes up in the routine evaluation of patients with rheumatoid arthritis and other autoimmune syndromes. The normocellular bone marrow suggests a peripheral destruction, in general, and raises some concerns for antibodies directed against neutrophils. These are ...
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Mednet MemberInvited Expert
Rheumatology · Uniformed Services University of the Health Sciences (USUHS)
Answered on · Updated on
Agree with @Dr. First Last.
For the young folk reading this thread (sorry to say we are not young folk, Paul), what we used to call "LGL syndrome" is now called RA-associated T-cell large granular lymphocyte leukemia. It used to sound a lot less scary to our patients when we could say LGL syndrome. ...
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