What is your approach to initiating JAK inhibitor therapy in patients for refractory inflammatory disease with a history of venous thromboembolism who are currently on anticoagulation?

A few questions: age of patient, nature of the "refractory" dermatitis, and prior therapies utilized in management...

No matter what the response, I would use a JAK inhibitor in a patient with a history of venous thromboembolism with extreme caution, given the black box warning of an elevated risk of...