What is your approach to management of recurrent Kikuchi-Fujimoto Disease?

My experience with recurrent Kikuchi–Fujimoto disease (KFD) is limited, as I have not managed many recurrences; however, this is the general framework I use in practice.

At the time of a recurrence, I first reassess the diagnosis and consider potential mimics—particularly infection, lymphoma, and evolving autoimmune disease, especially systemic lupus erythematosus.

For mild recurrences, I typically favor supportive care and NSAIDs with close clinical follow-up.

For moderate to severe presentations (e.g., significant pain, high fevers, bulky lymphadenopathy, or a prolonged course), I use a short course of systemic glucocorticoids, with dosing and taper tailored to disease severity. In the few cases I have treated, patients have been highly r...