What is your approach to managing Grover's Disease (Transient Acantholytic Dermatosis) that has failed topical steroids?

Topics: Dermatology • Acantholytic Disorders

Answer from: at Academic Institution

I'm a big fan of low-dose naltrexone for Grover's Disease (and Hailey-Hailey and Darier's Disease). It's a safe and effective treatment that I've seen work very well. The dose ranges between 1-5mg daily. It seems like 3mg is often the sweet spot. Patients sometimes report more trouble sleeping and/o...

Comments

at Kailua Dermatology Associates Ltd
In refractory cases, Dupixent is often effective.

at Rochester Regional Health Dermatology and Mohs Surgery
I find that Dupixent is effective though not frequ...

Answer from: at Academic Institution

Oral minocycline or doxycycline can help along with topical calcipotriene. Nb-UVB can also work for grovers if patients have access to treatment.

Answer from: at Academic Institution

IM Kenalog q 3-4 months.

Related Questions