What is your approach to managing patients with medically inoperable early stage endometrial adenocarcinoma who also cannot tolerate intracavitary brachytherapy (Rotte-Y, etc) as boost?

The curative-intent treatment of medically inoperable patients can be clinically challenging. Treatment is best individualized, taking into account their comorbidities, severity of disease, and other factors. Inoperability (unsuitable for hysterectomy) is largely due to serious medical comorbiditi...

@Dr. First Last has a very comprehensive answer and I agree with it. It is almost always possible to perform brachytherapy. Patients can be hospitalized and treated BID to avoid having to place the applicator more than once.

If I elect to offer radiation to a patient who cannot undergo brachytherapy...

We don’t need a Rotte-Y applicator in most in the era of image based approaches.

Research here and here.