I agree with Dr. @Bose, I generally treat with HMA and get to transplant if possible. Although there is data suggesting it may not be necessary, I usually prefer to get the blasts to <10%.
Answer from: Medical Oncologist at Academic Institution
I agree with Drs. @Bose and @Palmer, I like to add HMA as a bridge to transplant. If they are on a JAK inhibitor, I may keep it on per the MPD-RC HMA/Rux study. However, for patients who aren't on high doses, I have given HMA/Venetoclax in those that can tolerate it. The key, as Dr. Bose said, is to...