What is your preferred therapy for MDS/MPN with significant leukocytosis and neutrophilia?
For example, WBC >400k. Would you prefer a HMA vs hydroxyurea? When would you consider for bone marrow transplant?
Answer from: at Community Practice
Depends on blast count, cytogenetics, and molecular test results, age of patient, performance status, comorbidities, etc.
To bring the white count down can temporarily start with hydroxyurea. would use induction chemo versus HMA +/- venetoclax to achieve at least a partial response. can be a candid...