What is your approach to recurrent metastatic high-grade uterine carcinosarcoma with rhabdomyoblastic differentiation?
Is your approach more similar to systemic therapy for endometrial cancer, uterine sarcoma, or soft tissue sarcoma?
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What is your approach to the systemic treatment of recurrent metastatic high grade uterine carcinosarcoma with rhabdomyoblastic differentiation?
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2 Answers
Mednet MemberInvited Expert
Gynecologic Oncology · Cooper Medical School of Rowan University
Answered on
Carcinosarcomas (even with rhabdomyoblastic differentiation) are still considered to be derived from endometrial tissue. I would treat it as endometrial cancer and not as uterine or soft tissue sarcoma.
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Mednet MemberInvited Expert
Gynecologic Oncology · Washington University School of Medicine
Answered on
These cancers are shown to be derived from the endometrium, something called EMT (transformation).
I treat them as a poorly differentiated endometrial cancer. They are not sarcomas.
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