Indeed, JAKi seem to have a more broadly-acting antiinflammatory/immunosuppressive activity than some of our other DMARDs and biologics particularly. I have had a patient or two with EOA who have failed JAKs, but in almost all of those patients they initially had a good response, just with subsequen...

Entirely anecdotal, but the only medication class that I've had success with in erosive OA are JAK inhibitors. Usually, start with upadacitinib 15 daily.