What is your approach to refractory erosive osteoarthritis?
Significant impact on ADLs and no response to doxycycline, hydroxychloroquine, sulfasalazine or methotrexate.
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What medications do you use to treat severe erosive OA? Please select all that apply.
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2 Answers
Mednet MemberInvited Expert
Rheumatology · OU Medicine
Answered on
Indeed, JAKi seem to have a more broadly-acting antiinflammatory/immunosuppressive activity than some of our other DMARDs and biologics particularly. I have had a patient or two with EOA who have failed JAKs, but in almost all of those patients they initially had a good response, just with subsequen...
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Mednet MemberInvited Expert
Rheumatology · OU Medicine
Answered on
Entirely anecdotal, but the only medication class that I've had success with in erosive OA are JAK inhibitors. Usually, start with upadacitinib 15 daily.
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