What is your approach to treatment of infection-triggered HLH that does not respond to treatment of the underlying infection?
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What do you use to treat infection-associated HLH (non-EBV) that does not respond to underlying antimicrobial treatment?
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2 Answers
Mednet Member
Pediatric Hematology/Oncology · UCSF Medical Center-Mission Bay
Answered on
The algorithm our center follows is to
- Recognize hyperinflammation (see answer to question above -- in addition to baseline labs, we obtain an infectious disease consult)
- Look for and treat the trigger. A concern, if the patient is responding, is that we are missing a trigger (HLH does not occur sp...
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Mednet MemberInvited Expert
Hematology · Harvard Medical School
Answered on
Patients with infection-triggered HLH often require HLH therapy alongside treatment of the underlying infection, especially herpesvirus infections. Patients with infection-related HLH who are extremely ill with organ failure and severe symptoms usually require upfront HLH treatment along with treatm...
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