What is your approach to treatment of macrolide-sensitive localized bone/joint MAC disease?  

Agree with the above answers. Obviously, no strong clinical studies on duration and outcomes. At NJH, we typically recommend: Aggressive debridement/resection, Treat with appropriate antimicrobial therapy (in macrolide-S MAC, then AZM/EMB/Rifamycin +/- IV AMK) for a minimum of 6 months total, bu...

MAC infection in the bone is quite rare and very little is known about outcomes with any of the therapies. I have managed two patients recently, one with extensive wrist infection involving multiple bones and surrounding soft tissues, another with spinal osteo and paraspinal collection, and neither ...