What is your approach to treatment of macrolide-sensitive localized bone/joint MAC disease?

Agree with the above answers. Obviously, no strong clinical studies on duration and outcomes. At NJH, we typically recommend:

1. Aggressive debridement/resection,
2. Treat with appropriate antimicrobial therapy (in macrolide-S MAC, then AZM/EMB/Rifamycin +/- IV AMK) for a minimum of 6 months total, but a...

MAC infection in the bone is quite rare and very little is known about outcomes with any of the therapies. I have managed two patients recently, one with extensive wrist infection involving multiple bones and surrounding soft tissues, another with spinal osteo and paraspinal collection, and neither ...