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Topics:
Rheumatology • Spondyloarthritis
What is your approach to use of IL-17 inhibitors in patients with axial spondyloarthritis and a family history of inflammatory bowel disease?
If TNFi has failed, would you opt for JAK inhibition before trying IL-17i? Would you avoid IL-17i altogether?
Answer from: at Academic Institution
I would have no hesitation in using an IL-17i in an axSpA patient with family history of IBD as long as the patient themselves do not have active IBD. Clinical trials on Secukinumab, Ixekizumab and Bimekizumab did not exclude patients with history of IBD, and family H/O IBD was not recorded. Active...
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