What is your approach to use of IL-17 inhibitors in patients with axial spondyloarthritis and a family history of inflammatory bowel disease?
If TNFi has failed, would you opt for JAK inhibition before trying IL-17i? Would you avoid IL-17i altogether?
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How do you use anti-IL-17 agents in patients with axial spondyloarthritis and a family history of IBD?
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1 Answer
Mednet MemberInvited Expert
Rheumatology · OHSU
Answered on
I would have no hesitation in using an IL-17i in an axSpA patient with a family history of IBD as long as the patient themselves do not have active IBD. Clinical trials on Secukinumab, Ixekizumab, and Bimekizumab did not exclude patients with a history of IBD, and family H/O IBD was not recorded. Ac...
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