I only recommend treatments that have been shown to be effective in randomized, double-blinded, placebo or sham-controlled trials and that, in terms of their ability to show benefit, are supported by a properly conducted power calculation. Per the FDA, open-label trials are solely conducted for the ...
That particular study by Gutierrez et al., PMID 40391557, did not address the efficacy/safety of ONS in chronic/refractory cluster headache disorder, but it was in occipital neuralgia/cervicogenic headache populations.In a randomized controlled trial by Wilbrink et al., PMID 34146510,131 study parti...