It is important to recognize, that while most H3K27M mutant midline gliomas in young adults are high grade (GBM equivalent), some are actually histologic, more benign tumors (although they tend to occur in other locations). Therefore, a correct histological diagnosis is still necessary. My preferenc...

Have treated a couple of these recently, and the only thing they responded to was radiation.  In one patient, I gave only 54 Gy as it was in the middle of the brainstem and they tried every systemic therapy without success, before having another brief response to reirradiation (only to 36Gy), ...