Intra-articular glucocorticoids have been used for decades to treat painful knee osteoarthritis. In the past, steroid preparations of relatively insoluble crystals such as triamcinolone hexacetonide were used with the intention of prolonging the duration of intraarticular action. Although the retent...

@Joel A. Block gives a fantastic medical literature review above. I'll add my own experience. I've been using Zilretta regularly for about 3 1/2 years, and it really has done wonders for some of my patients. I always use US guidance (as @Michael Weisman alludes to, I always want to ensure per...