Do GLP-1 agonists have measurable anti-inflammatory effects in diseases like RA or spondyloarthropathies beyond weight loss?

There is currently no evidence of efficacy in chronic inflammatory arthritis. Due to their mechanism of action, we can hope that they will be effective because of their anti-inflammatory and immunomodulatory properties, which have been well demonstrated in numerous experimental models. But only rand...

Adipose cells release IL-6 and raise CRP. It sound logic that weight reduction would add both a biochemical and mechanical reduction on joints overall.