Do GLP-1 agonists have measurable anti-inflammatory effects in diseases like RA or spondyloarthropathies beyond weight loss?
This question is part of our collaboration with ACR Convergence 2025 to preview a session from this year's meeting. This question is inspired by the upcoming session "GLP1 Agonists in Rheumatic Disease and Osteoarthritis: Should We Give Them to Everyone?" by Dr. C. Thomas Appleton and Dr. @Dr. First Last.
2 Answers
Mednet MemberInvited Expert
Rheumatology · Sorbonne Université
Answered on
There is currently no evidence of efficacy in chronic inflammatory arthritis. Due to their mechanism of action, we can hope that they will be effective because of their anti-inflammatory and immunomodulatory properties, which have been well demonstrated in numerous experimental models. But only rand...
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Mednet MemberInvited Expert
Rheumatology · U.S. Department of Veterans Affairs
Answered on
Adipose cells release IL-6 and raise CRP. It sound logic that weight reduction would add both a biochemical and mechanical reduction on joints overall.
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