Topics:
Hematologic Malignancies • Medical Oncology • Geriatrics Oncology • Myeloma • NCI-CCC Tumor Board Question • Mayo Clinic • NCI-CCC Myeloma Tumor Board Question
What is your experience with using Frailty Index or other geriatric screening in making decisions for elderly patients with multiple myeloma?
Frailty Index per Palumbo et al. PMID 25628469
Is it practical to apply in clinics? Have you made decision changes based on it?
Answer from: Medical Oncologist at Community Practice
The IMWG frailty score is the most comprehensive score developed to date. While predictive, trials testing its value prospectively are ongoing. Linking age, comorbidities (Charlson), and functional scales (ADL & IADL) makes great logical sense. I don't use it. The UKMRA Myeloma XIV FiTNEss ...
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Answer from: Medical Oncologist at Academic Institution
I completely agree with everything @Craig C. Hofmeister said, in particular, the details of lenalidomide and dexamethasone (including that wonderful trial by Larocca et al., PMID 33739404!)At our center, we don't routinely use the IMWG frailty index for predictable reasons - not implemented into wor...