What is your loading dose goal and typical loading regimen for PO amiodarone in patients with atrial fibrillation?

I generally aim for a loading dose of 10 grams. This is a combination of both IV and PO amiodarone administered. For an outpatient, I utilize one of the original dosing schedules consisting of 200 mg TID x 3 weeks, followed by 200 mg daily (although this is a little more than 10 grams). For an inpat...

I dose amiodarone differently when treating AF compared to when treating VT. For AF, assuming that the patient has been adequately anticoagulated since we are not dealing with a life-threatening arrhythmia, I generally do an initial loading of 400mg BID for 7 days and then cutting back to 200mg dail...

I agree with all the above. These answers are very helpful.

The one time when I am cautious and don't use this loading protocol is when I am not sure if the patient will have a close follow-up.

It has not happened to me personally, but I have heard of cases where patients did not follow up as schedu...

I don’t think there is a consensus or guidelines on this. For atrial fibrillation rhythm control, the goal is generally 6-10 grams loading dose. Outpatient I would do 400 mg bid for 1 week, 400 mg QD for 2-4 weeks then 200 mg QD as maintenance. As an inpatient oral load is 400 mg TID x 5 days, or IV...