What is your methotrexate initiation strategy in DMARD-naive RA patients?

Best final dose is 20 to 25 mg per week, not 15 mg per week. D Furst

Starting with 10-15 mg/week, monthly labs x 3 months, then every 3 months thereafter for CBC +diff, AST, Creatinine; assessment at 3 months with up-titration.

If started with 10 mg/week, up-titrate to 15 mg in 2-4 weeks if well tolerated.