What is your preferred comprehensive nodal irradiation approach in non-metastatic breast cancer patients with underlying respiratory diseases or poor baseline respiratory function in light of the findings from the RadComp Trial?

The RadComp trial PRO-CTCAE item for no shortness of breath versus any shortness of breath significantly favored protons as reported in the abstract. However, after correction for multiplicity, this became non-significant, meaning there was no difference. While multiplicity analyses ensure that fals...

I would also add that for someone with such poor lung function, the absolute benefit of treatment has to be weighed against the risk of non-cancer morbidity and mortality.

Also threshold to reduce the volume of treatment, like prophylactic IMN, should be low to meet tighter lung constraints.