What is your preferred first-line therapy for transfusion-dependent beta-thalassemia?

Transfusion is my preferred first-line therapy (and standard of care) for beta-thalassemia major. For beta-thalassemia intermedia that has evolved into TDT, my preferred first-line treatment is mitapivat over luspatercept, particularly if the patient has extramedullary masses (that have been noted t...