What is your preferred imaging modality for determining infarct core when evaluating acute stroke cases?  

MRI is the best imaging modality for determining core infarct, but non-contrast head CT and CT perfusion imaging are more practical and faster, so they are used by a vast majority of centers. I use CT and CTP because they are much faster to obtain at my institutions.

Here is my simplified algorithm I use in most cases for deciding on both TNK and thrombectomy. First line is CT and CTA head and neck, looking at ASPECTS and collateral flow. If both favorable and within 4.5h for TNK and 6h for thrombectomy, proceed with treatment. If presenting beyond 6h, I add CT...

I agree with prior responses. In most cases, a combination of CT & CTA with ASPECTS scoring & collateral assessment is sufficient to determine infarct core burden. I don't routinely rely on MRI for EVT or thrombolysis assessment due to logistical and/or time constraints. CTP can be hit or mi...

I like Aspects also, although at times I use MRI.

I agree with the above answers. ASPECTs on non-contrast CT and CTA collateral assessment for anterior circulation. CTP may add some value for anterior circulation distal occlusion, but more so for the penumbra, as sometimes, if there is perfusion in the infarcted tissue, it may not meet the core thr...