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Vascular Neurology   

Questions discussed in this category

What is your strategy for treating persistent headaches in the aftermath of subarachnoid hemorrhage?
Does your strategy change depending on whether or not it is a secured or unsecured aneurysmal SAH?
4 Answers available
Does aspirin dose (81 mg vs 325 mg) matter for secondary stroke prevention?
Should some patients get 325 mg instead of 81mg at least for a certain amount of time, such as patients in the acute phase of ischemic stroke or patie...
1 Answer available
Should follow-up imaging for unruptured intracranial aneurysms include MRA head and MRI brain to evaluate for arterial wall enhancement?
1 Answer available
Is there a good rationale for using vasopressors/induced hypertension in a patient with fluctuating neurologic deficits from symptomatic intracranial stenosis?
2 Answers available
Would you recommend a CT venogram or MR venogram in patients with concern for venous sinus thrombosis?
1 Answer available
What do you advise regarding the timing and safety of major surgery in patients with moderate to severe intracranial atherosclerosis?
Does your approach differ if the stenosis is symptomatic or flow-limiting?
1 Answer available
Would you recommend TNK or DAPT in patients with stroke-like symptoms and NIHSS less than 5 presenting within 4.5 hours?
4 Answers available
When is brain biopsy useful/warranted as part of the diagnostic work-up in patients with suspected primary CNS angiitis?
3 Answers available
Can bleeding risk when switching from VKA treatment to a NOAC in frail, elderly patients be accurately compared if individual times in therapeutic range while on VKA treatment are not captured?
Individual times in the therapeutic range while on VKA treatment was not registered in FRAIL-AF.
2 Answers available
Regarding CVST, what protocol of heparin dosing do you regularly use and does it change depending on clot burden/ICH status?
Is there any evidence supporting the use of heparin boluses?
2 Answers available
Do you screen adults in your practice with sickle cell disease for silent cerebral infarcts?
The ASH 2020 guidelines have "recommended that adults with HbSS or HbSβ0 thalassemia be screened at least once for silent cerebral infarcts even ...
1 Answer available
What is your approach to the treatment of idiopathic intracranial hypertension with transverse sinus stenosis?
Do you favor specific medications or surgical interventions?
1 Answer available
Would you administer IV thrombolysis in a patient presenting with disabling stroke symptoms while on anti-amyloid therapy?
4 Answers available
When do you use MRI to evaluate patients with spontaneous subdural hemorrhage?
In light of the evidence associating cerebral amyloid angiopathy (CAA) with subdural hemorrhage; Rivier et al., PMID 38147345.
1 Answer available
Would you discontinue romosozumab in a patient who develops a hemorrhagic stroke while on therapy?
5 Answers available
When would you consider neuro-stimulants in post-stroke patients?
Is there management guidance on when to start after stroke onset?
1 Answer available
Do you typically use NOACs or Lovenox in patients with stroke due to hypercoagulability from malignancy?
1 Answer available
Do you avoid SSRIs in patients with a history of RCVS?
2 Answers available
How often do you screen for cerebral aneurysms in patients with autosomal dominant polycystic kidney disease who do not have a family history of intracranial aneurysms or for whom the family history is unknown?
1 Answer available
When do you re-image patients with a diagnosis of venous sinus thrombosis?
2 Answers available
Should perfusion imaging be the standard of care in cases of a severe symptomatic intracranial stenosis?
If yes, is there a preference with MRI or CT technique?
5 Answers available
Is perfusion imaging reliable in determining stroke infarct vs. area at risk?
2 Answers available
How do you manage asymptomatic patients with incidental findings of the carotid web?
2 Answers available
Does anyone utilize P2Y12 assays to determine if clopidogrel may be ineffective when used for DAPT?
If yes, if the assay shows they are a non-responder, do you switch to ticagrelor?
2 Answers available
What is the preferred approach to managing non-occlusive or partially occlusive venous sinus thrombosis?
1 Answer available
When do you consider treating intracerebral hemorrhage associated with cerebral amyloid angiopathy as an inflammatory CAA?
How would you treat it?
1 Answer available
Would you recommend genetic polymorphic testing before the initiation of antiplatelet medication in patients with ICAD?
4 Answers available
What is your approach to the management of asymptomatic intracranial atherosclerosis discovered during the workup of an acute stroke?
Does it influence your choice of antithrombotic therapy? Do you perform serial follow-up imaging?
2 Answers available
What blood pressure targets do you enforce in the first 24-48 hours in a patient who develops an intracranial hemorrhage after mechanical thrombectomy?
Blood pressure targets for ischemic stroke and intracerebral hemorrhage are described in several guidelines. However, in patients with acute stroke wh...
1 Answer available
How do you manage incidentally found venous sinus thrombosis?
5 Answers available
What is your approach to secondary stroke prevention in patients with atrial fibrillation and intracranial stenosis (>70%)?
3 Answers available
Would you consider dual antiplatelet therapy for stroke prevention for ICAD in patients with a history of SAH?
2 Answers available
What criteria are used to choose a specific dose of aspirin in ischemic stroke?
We have seen 81 vs 162 vs 325 mg up to 1300 mg.
3 Answers available
Would you give TNK or IVT to a patient with proximal occlusion and an NIHSS of 0-3 (non-disabling)?
How about a distal occlusion? The patient was initially symptomatic but symptoms improved or mostly resolved.
5 Answers available
What duration of dual antiplatelet therapy do you use for secondary prevention of ischemic stroke due to intracranial atherosclerotic disease?
While some have the practice of 90 days per SAMMPRIS trial, the lower rates of ischemic stroke in the medical therapy group were driven by events with...
8 Answers available
Do you start aspirin for patients with incidentally found intracranial vertebral stenosis?
3 Answers available
When do you refer patients diagnosed with Moyamoya disease to neurosurgery?
2 Answers available
How do you address incidental small cerebellar infarcts seen on MRI?
This is not an infrequent finding in outpatient neurology practice, often in the absence of any lacunar disease in the typical regions, though I usual...
3 Answers available
How do you acutely manage a free-floating thrombus in a major artery in a patient with a stroke as a result of it?
4 Answers available
Would you change an elderly, frail patient with atrial fibrillation who is already on a NOAC to VKA treatment?
In FRAIL-AF, switching VKA therapy to a NOAC was associated with higher risk of bleeding in elderly, frail patients. 
4 Answers available
Do you think that home INR monitoring is a feasible option for elderly, frail patients with atrial fibrillation on VKA treatment, given variations in socioeconomic status and access to care?
2 Answers available
Do you consider bleeding risk in elderly, frail patients with atrial fibrillation to be similar for all NOACs?
In FRAIL-AF, participants were switched from VKA to dabigatran, rivaroxaban, apixaban, and edoxaban.
2 Answers available
What would be the clinical benefit of multiphase CTA over CTP?
Should MTCTA be standard for anyone with LKN>=6h?
4 Answers available
Do you usually recommend PFO closure for patients with frequent migraines with aura?
1 Answer available
When should one consider obtaining a cardiac MRI in ischemic stroke patients?
What is the utility of it? 
1 Answer available
When do you restart antiplatelet therapy in patients with hemorrhagic conversion of stroke?
2 Answers available
Would you recommend anti-platelet or anticoagulation in a patient with recurrent strokes, CADASIL, and Antiphospholipid Syndrome?
1 Answer available
Do you routinely screen for sleep apnea in patients with acute ischemic stroke?
3 Answers available
For patients with acute ischemic stroke and BP >185/110, at what point do you consider persistently elevated BP too refractory to safely give thrombolysis?
Current guidelines (AHA, ESO etc) are not clear. In addition, if a patient arrives with BP>240 how do you balance risk of hypoperfusion with excess...
4 Answers available
What is the recommended approach for extracranial bleeding after tPA?
Fibrinogen level >200.
2 Answers available
Considering only cerebrovascular indications, are there circumstances in which you would use aspirin along with a DOAC in patients with atrial fibrillation and stroke?
6 Answers available
In antiphospholipid syndrome with recurrent strokes, would you consider adding antiplatelets to warfarin?
Also how would you manage this perioperatively?
7 Answers available
For patients with ischemic stroke status-post decompressive hemi-craniectomy, when should they start aspirin for secondary stroke prevention?
For patients with ischemic stroke status-post decompressive hemi-craniectomy, when should they start aspirin for secondary stroke prevention? POD 5? P...
2 Answers available
How do you approach a patient with atrial fibrillation on apixaban who has a new cardioembolic stroke?
3 Answers available
In patients with Afib on anticoagulation and concurrent intracranial atherosclerotic disease, would you consider adding an anti-platelet to anticoagulation if there are recurrent events that could be related to the ICAD?
1 Answer available
In patients with embolic stroke and a PFO, how often do you go beyond venous Doppler of the lower extremities to screen for DVT (e.g. MRV or CTV abdomen and pelvis)?
Would you anticoagulate if this screening is negative pending PFO closure?
1 Answer available
Would you start anticoagulation in a patient with a history of CVA 1 year ago and high risk APL profile who was never started on anticoagulation, but is now presenting for follow up and without recurrent thrombotic events?
The patient has no known history of autoimmune disease.
4 Answers available
How do you approach the treatment of biopsy proven ABRA (amyloid beta related angiitis)?
2 Answers available
Is there a preference between the different high-intensity statins for high-risk stroke patients?
How does pravastatin differ in advantage from other high-intensity statins?
3 Answers available
Does the presence and location of cerebral microbleeds affect your decision for antithrombotic treatment in patients with atrial fibrillation?
Do you distinguish between primary and secondary prevention? Wilson et al., PMID 31130428 is helpful, but curious how people apply this data in practi...
3 Answers available
When can you utilize external ventricular drains (EVDs) in the management of posterior fossa strokes?
Do all malignant posterior fossa infarcts need sub-occipital craniectomy or are there a subset of cases that can be managed with EVD? 
1 Answer available
What additional testing besides LAC/APLS, factor V Leiden, prothrombin gene mutation, JAK 2 do you draw for unprovoked cerebral venous sinus thrombosis?
1 Answer available
Would you recommend PFO closure in patients >60 years old with presumed paradoxical embolism as their mechanism of stroke?
2 Answers available
What guidance do you provide for anesthesia in patients with incidentally found carotid web?
1 Answer available
Do you recommend life long aspirin 81mg daily for non-specific T2 white matter hyper-intensities on MRI brain?
7 Answers available
What blood pressure goals do you typically target for patients in the immediate post thrombectomy period?
2 Answers available
Do you typically recommend inpatient stroke evaluation for patients with incidentally found asymptomatic stroke on outpatient imaging?
For patients undergoing outpatient MR imaging for other indications who have instantly found acute stroke, do you typically recommend the patient be a...
5 Answers available
Do you consider a severe ICA stenosis (70-99% narrowing per NASCET criteria) symptomatic if a lacunar stroke attributable to small vessel disease occurs in the perforating arteries (e.g. lenticulostriate) downstream from the stenosis?
Do you offer this person a vascular intervention (i.e. CEA or stenting)?
1 Answer available
What pre-operative work-up do you follow in your institution prior to EC-IC bypass in patients with a focal intracranial stenosis and patients with MMD?
1 Answer available
Is there a role to continue aspirin in patients with myeloproliferative disorders who have never had a thrombotic event that are starting DOAC for stroke prophylaxis with newly diagnosed atrial fibrillation?
2 Answers available
How long do you wait before foley or IV placement in patients who have recieved TNK or TPA?
3 Answers available
What are current strategies to treat severe symptomatic basilar stenosis failing medical therapy?
2 Answers available
How do you define impaired distal fusion in patients with ICAD?
In what ways, if any, does the timing of perfusion imaging from onset of stroke symptoms affect its utility in informing quality of distal perfusion?
2 Answers available
Would you recommend switching to DAPT for patients on anticoagulation who develop symptoms of a TIA secondary to ICAD?
3 Answers available
How can you differentiate perforator disease vs artery-to-artery embolus as a stroke etiology?
1 Answer available
How would you manage anti-platelet therapy in patients presenting with ischemic stroke and have a history of von Willebrand disease?
1 Answer available
What antithrombotic regimen do you recommend prior to and in anticipation of CEA for patients with symptomatic carotid stenosis?
2 Answers available
Would you give IV thrombolysis to a patient presenting with acute disabling stroke symptoms after a TAVI procedure?
1 Answer available
When do you start anticoagulation in patients with endocarditis and evidence of mycotic aneursym?
3 Answers available
How will you treat a young man with recurrent cryptogenic strokes with no identifiable cause, with MTHFR A1298C homozygous mutation and normal homocysteine level?
1 Answer available
Do you typically recommend four factor prothrombin complex concentrate versus fresh frozen plasma for INR correction in patients with vitamin K antagonist associated spontaneous ICH?
4 Answers available
Is angioedema secondary to IV tPA considered an absolute contraindication for tPA in future?
3 Answers available
Is LP indicated for patients with recurrent thunderclap headaches over a 4-week period and negative head imaging for SAH?
2 Answers available
Do you recommend antiplatelet therapy for patients who have suffered stroke due to CADASIL?
3 Answers available
Would you favor restarting anticoagulation or pursuing left atrial appendage closure in a patient with hemorrhagic stroke on anticoagulation for non-valvular atrial fibrillation?
3 Answers available
What is your practice for the timing of resumption of oral anticoagulation after ICH?
Do you order any imaging beforehand? Are there other studies that you order?  
1 Answer available
What is the recommended management approach in regard to diagnostic evaluation and treatment for patients with homocystinuria and cerebral thrombosis?
Do we prophylactically place patients on anticoagulation after one episode? Besides MRI/MRV brain, are there other diagnostic imaging that should b...
1 Answer available
Are triptans contraindicated in patients with Moya Moya syndrome who have never had an ischemic stroke?
2 Answers available
Do you typically recommend platelet transfusions in patients with spontaneous ICH?
Do you have a particular cutoff?
2 Answers available
When do you recommend MRA in patients with spontaneous ICH and negative CTA?
Do you ever recommend any specific sequences on MRA?
3 Answers available
Do you typically recommend CT angiogram and CT venogram to assess for patients with lobar spontaneous ICH?
2 Answers available
Do you always pursue stroke work up in patients diagnosed with transient global amnesia?
For patients clinically presenting with Transient Global Amnesia and no other focal neurologic deficits, do you always pursue work up to rule out stro...
8 Answers available
Does the overall conclusion of the CHANCE-2 trial make ticagrelor + ASA a worthwhile transition given the data showing cumulative hazard of stroke diverged during the first week and was subsequently similar, which suggests the benefit of ticagrelor over clopidogrel is seen predominantly soon after stroke?
4 Answers available
Is there a risk of CYP2C19 gene testing only being adopted by wealthier health systems, thereby creating a disparity gap in treatment?
What is the cost and accessibility of CYP2C19 gene testing? Does the limited availability of rapid genotyping techniques limit the clinical applicabil...
3 Answers available
Do you ever do surveillance MR imaging in patients with stable exam and history of cardioembolic stroke?
1 Answer available
Would you generalize the data from the CHANCE-2 trial to a broader clinic population given that the study was specific to Han Chinese patients?
How do you plan to incorporate the results of the CHANCE-2 trial (Wang et al., PMID 34708996) in your own practice?
3 Answers available
Do you recommend genetic testing after a patient on clopidogrel has a stroke based on the results of the CHANCE-2 trial?
3 Answers available
Would you consider anticoagulation for a young patient with a recent embolic stroke and newly diagnosed global cardiac hypokinesis with ejection fraction of less than 25%?
No thrombus detected on echocardiogram and no evidence of atrial fibrillation is present.
1 Answer available
Would you recommend short-term dual antiplatelet therapy for a patient who received tPA, and is otherwise eligible for dual antiplatelet therapy per POINT or SAMMPRIS trial?
3 Answers available
What is your approach for a patient with an acute ischemic stroke caused by an aortic thrombus?
2 Answers available
How would you approach protein S deficiency found on hypercoagulability work-up in a patient with a post-operative central retinal vein occlusion?
In the setting of no personal or family history and no other risk factors for thrombosis, is systemic anticoagulation warranted if local treatments (e...
4 Answers available
How long after starting anticoagulation would you remove an IVC filter in a patient with a DVT presenting with stroke and PFO which is now closed?
1 Answer available
What is your approach to a patient who has an ischemic stroke while on clopidogrel despite strict compliance and normal results on clopidogrel response assay?
5 Answers available
How do you decide between TCAR vs. carotid stenting for patients unstable for CEA?
2 Answers available
When do you start anticoagulation in a patient with cardioembolic CVA secondary to new onset atrial fibrillation with hemorrhagic conversion?
1 Answer available
How does evidence of cerebral amyloid angiopathy/microbleeds affect choices for secondary stroke prevention in patients with a history of ischemic stroke and atrial fibrillation?
How do you approach secondary stroke prevention for patients with ischemic stroke, atrial fibrillation, and signs of cerebral amyloid angiopathy/micro...
1 Answer available
How do you determine timing and frequency of stability scans for a patient with spontaneous, non-aneurysmal intracerebral hemorrhage?
What factors influence your thinking?
1 Answer available
Do you use a combination of anticoagulant and antiplatelet therapy for treating intraluminal internal cerebral artery thrombus causing stroke?
For what duration do you use therapy?
1 Answer available
Would it be prudent to complete long term cardiac monitoring (ie. 30 day) in a patient with a new typical appearing lacunar type thalamic infarct and history of hypertension?
1 Answer available
Is antiplatelet or anticoagulant therapy preferred for the secondary prophylaxis of cryptogenic stroke in a patient with underlying malignancy?
4 Answers available
Do you treat cerebral vein thrombosis with parenchymal hemorrhage using full dose heparin protocol rather than the high risk protocol?
1 Answer available
Do you start anticoagulation in a patient with infective endocarditis who also has atrial fibrillation and stroke?
1 Answer available
For patients with atrial fibrillation on DOAC, when should they resume DOAC after a thalamic bleed without intraventricular bleed?
How does presence of intraventricular hemorrhage change your recommendations?
2 Answers available
When do you consider middle meningeal artery embolization in patients with recurrent subdural hemorrhages?
In what clinical scenario would you refer a patient for embolization? Are there any contraindications? 
1 Answer available
For which stroke patients, if any, do you recommend implantable loop recorder for long-term cardiac monitoring and why?
It seems clear that longer monitoring yields more AF detected. What is less clear to me is whether all ILR-detected AF is relevant and merits anticoag...
1 Answer available
How do you determine if a patient is safe to drive after having a PCA infarct?
What is the best way to determine if patients with new PCA territory infarct can drive? Upon discharge from the hospital, do you routinely refer them ...
1 Answer available
What is your steroid-sparing agent of choice to treat GCA given the current tocilizumab shortage?
Thoughts on sarilumab vs methotrexate, or just treat with steroids alone
1 Answer available
How do you treat patients with symptoms of acute ischemic stroke who have an allergic reaction to alteplase?
How would you treat patients with symptoms of AIS who have an allergic reaction to TPA with no evidence of large vessel occlusion on imaging? What nex...
1 Answer available
When do you start anticoagulation for secondary prevention in patients with HFrEF and history of embolic strokes?
For a relatively young, medically compliant patient with HFrEF (EF<35%) and h/o embolic stroke, what is the consensus of starting AC for secondary ...
1 Answer available
When is the best time to consider left atrial appendage closure for secondary stroke prevention in patients with atrial fibrillation?
For example, with a Watchman device? What is the evidence behind this?
1 Answer available
When do you restart anticoagulation in patients with atrial fibrillation who just had an ischemic stroke?
1 Answer available
When do you consider starting hypertonic saline solution in patients with an acute ischemic stroke?
1 Answer available
How do you approach management of cerebral venous sinus thrombosis in a patient with severe thrombocytopenia?
1 Answer available
Should patients who have had hemorrhagic strokes be restarted on oral anticoagulation?
If so, how do you decide when to restart anticoagulants?
1 Answer available
How do you determine the timing of anticoagulation for patients with large MCA strokes secondary to atrial fibrillation?
1 Answer available
Should patients with cerebral amyloid angiopathy have any statin medications discontinued?
1 Answer available
In what clinical settings is acute ICH clot removal recommended?
1 Answer available
In patients with recurrent ischemic infarcts on the same side as an internal carotid artery lesion, is intervention warranted even if there is less than 50% obstruction?
When would you consider stenting or CEA even if there is less than 50 obstruction when no other etiology has been found?
1 Answer available
How do you limit the onset of new strokes in patients with Moya-Moya syndrome?
1 Answer available


Papers discussed in this category

American journal of hematology, 2023 May 12
An integrated therapeutic approach to sickle cell disease management beyond infancy.
The New England journal of medicine, 2014 Aug 21
More blood for sickle cell anemia?
Stroke, 2020 Aug 06
Anticoagulation Type and Early Recurrence in Cardioembolic Stroke: The IAC Study.
Neurology. Clinical practice, 2018-02
Anticoagulation for atrial fibrillation after intracranial hemorrhage: A systematic review.
Stroke, 2015 May 28
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.
Stroke, 2019-02
Ischemic Stroke and Internal Carotid Artery Web.
Stroke, 2011-04
Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association.
Ann Neurol, 2020 Aug 05
Anticoagulation Timing in Cardioembolic Stroke and Recurrent Event Risk.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019-08
Treatment Approaches to Lacunar Stroke.
Stroke, 2021 Sep 14
Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities.
Stroke, 2015-03
Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis.
BMJ open, 2014-12-02
Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study.
J Am Coll Cardiol,
Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial.
Neurology, 2015-09-29
Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE.
Stroke, 2017-08
Challenges in the Medical Management of Symptomatic Intracranial Stenosis in an Urban Setting.
Stroke, 2021 May 24
2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.
Lancet (London, England), 2014-01-25
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
Circulation, 2019-08-20
Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke.
J Neurol, 2021 Jul 17
Frequency of silent brain infarction in transient global amnesia.
J Vasc Surg, 2019 Dec 31
Duration of blood flow reversal during transcarotid artery revascularization does not affect outcome.
The New England journal of medicine, 2012-05-17
Warfarin and aspirin in patients with heart failure and sinus rhythm.
The New England journal of medicine, 2018-10-04
Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.
The New England journal of medicine, 2019-05-16
Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.
Heart, 2019 Apr 08
Anticoagulation therapy in heart failure and sinus rhythm: a systematic review and meta-analysis.
N Engl J Med,
Trial of Tocilizumab in Giant-Cell Arteritis.
Lancet, 2016 Mar 04
Tocilizumab for induction and maintenance of remission in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial.
Arthritis Rheum,
Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis.
American heart journal, 2010-07
Cryptogenic Stroke and underlying Atrial Fibrillation (CRYSTAL AF): design and rationale.
Lancet, 2021 Aug 27
Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial.
Neurology, 2019 Jan 11
RCVS score and diagnostic approach for reversible cerebral vasoconstriction syndrome.
The New England journal of medicine, 2013-03-21
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.
Neurology, 2013-08-13
An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke.
The New England journal of medicine, 2017-09-14
Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.
Circ Cardiovasc Interv, 2022 Jun 23
Transcatheter Closure of Patent Foramen Ovale in Older Patients With Cryptogenic Thromboembolic Events.
JAMA, 2021 Dec 14
Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.
JAMA Neurol, 2020 Jul 01
Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke.
JAMA Neurol, 2022 Nov 01
Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure.
Neurology, 2015-10-13
Clinical Reasoning: An 87-year-old woman with left-sided numbness.
JAMA,
Effect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: The STROKE-AF Randomized Clinical Trial.
eNeurologicalSci, 2017 Aug 02
Successful systemic thrombolysis with rtPA in a patient with history of a life-threatening rtPA-associated orolingual angioedema.
Neurol Clin Pract,
Thrombolysis of a stroke patient with history of rtPA-associated angioedema.
J Am Heart Assoc, 2020 Nov 23
Direct Oral Anticoagulants in Patients With Inherited Thrombophilia and Venous Thromboembolism: A Prospective Cohort Study.
Am J Hematol,
Protein S abnormalities: a diagnostic nightmare.
Eur J Neurol, 2017 Aug 20
European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology.
Stroke, 2016 Dec 20
Optimal Timing of Anticoagulant Treatment After Intracerebral Hemorrhage in Patients With Atrial Fibrillation.
Stroke, 2010 Oct 28
Optimal timing of resumption of warfarin after intracranial hemorrhage.
J Thromb Haemost, 2010 Apr 08
Management of anticoagulation following central nervous system hemorrhage in patients with high thromboembolic risk.
Lancet Neurol, 2021 Sep 03
Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial.
The New England journal of medicine, 2018-07-19
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
N Engl J Med, 2013 Jun 26
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.
N Engl J Med, 2021 Oct 28
Ticagrelor versus Clopidogrel in Loss-of-Function Carriers with Stroke or TIA.
N Engl J Med,
Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.
JAMA neurology, 2019-04-01
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.
Lancet Neurol, 2019 May 23
Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.
JAMA Neurol,
Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016.
Lancet Neurol, 2018 Jan 10
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study.
Cancer causes & control : CCC, 2010-03
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Atherosclerosis, 2001-06
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
The American journal of clinical nutrition, 2008-10
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Circulation. Cardiovascular genetics, 2008-12
Variants of folate metabolism genes and the risk of conotruncal cardiac defects.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012-01
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
Human genetics, 2012-05
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.
PeerJ, 2013
Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.
Nature, 2016-08-18
Analysis of protein-coding genetic variation in 60,706 humans.
Am J Hum Genet, 1998 May
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Am J Reprod Immunol, 2011 Jan 18
Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss.
Am J Reprod Immunol, 2012 Aug 06
Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome.
BMC Cancer, 2008 Nov 07
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
BMJ Case Rep, 2012 Nov 15
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation.
BMJ Case Rep, 2013 Jun 13
Bilateral consecutive optic neuropathy in a patient with thrombophilia.
Mol Biol Rep, 2010 Jun 08
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk.
Mol Biol Rep, 2010 Nov 16
Association of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer cases.
Nat Genet, 2008 Jul
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Proc Natl Acad Sci U S A, 2001 Mar 13
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Mol Biol Rep, 2018 Mar 29
CBS mutations and MTFHR SNPs causative of hyperhomocysteinemia in Pakistani children.
Transfus Apher Sci, 2014 Jan 08
Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphisms with retinal vein occlusion in Tunisian patients.
J Matern Fetal Neonatal Med, 2015 Jul 02
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