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What is your preferred protocol for squaric acid (SADBE) treatments for alopecia areata/totalis?

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Mednet Member
Mednet Member
Dermatology · UCLA Health

Based on a few series published showing that sensitization is not necessary for contact immunotherapy, I tend to do one of two things:

  1. Start patients at squaric acid 0.001% solution every other day at home and increase the concentration by 10 (0.01%, then 0.1%, then 0.5%) monthly if not reacting.
  2. ...

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