What is your preferred salvage chemotherapy regimen for bridge to auto SCT for patients with relapsed classical Hodgkin Lymphoma?
2 Answers
Mednet Member
Medical Oncology · Rutgers Cancer Institute of New Jersey
We actually have been favoring using a bendamustine-brentuximab based regimen (in those who have not received brentuximab in the front line setting). Supportive data is based on Lancet Oncol. Feb 2018 that showed a favorable toxicity profile with an almost 80% ORR.
Usually will give 2-3 cycles, rest...
Mednet Member
Medical Oncology · University of Maryland Cancer Center
Honestly, the most important point is to achieve CMR on PET/CT before AutoSCT, rather than how to achieve it. Brentuximab vedotin-based regimens (if not received in 1L treatment) are mostly used as single agent or in addition to bendamustine.