Mednet Logo
CommunityHematology

What is your preferred treatment for refractory warm autoimmune hemolytic anemia with autoimmune neutropenia?

No response to steroids or rituximab. No evidence of hematologic malignancy on bone marrow biopsy.
2 Answers
Mednet Member
Mednet MemberInvited Expert
Hematology · University of Rochester School of Medicine and Dentistry
Answered on

For immunomodulation, have you trialed IVIG? If not, this would be worth a trial.

For immunosuppression, I prefer to utilize a more T cell-directed agent after failure of steroids/rituximab. Thus, a trial of MMF or cyclophosphamide may be reasonable. I think MMF may take too long to work in a situat...

Join for free or sign in to see the full answer

Mednet Member
Mednet Member
Hematology · University of Rochester Cancer Center
Answered on

Based on no personal experience, the literature suggests that daratumumab might be a reasonable second or third-line agent for autoimmune cytopenias.

Join for free or sign in to see the full answer