What is your preferred treatment for refractory warm autoimmune hemolytic anemia with autoimmune neutropenia?
No response to steroids or rituximab. No evidence of hematologic malignancy on bone marrow biopsy.
2 Answers
Mednet MemberInvited Expert
Hematology · University of Rochester School of Medicine and Dentistry
Answered on
For immunomodulation, have you trialed IVIG? If not, this would be worth a trial.
For immunosuppression, I prefer to utilize a more T cell-directed agent after failure of steroids/rituximab. Thus, a trial of MMF or cyclophosphamide may be reasonable. I think MMF may take too long to work in a situat...
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Mednet Member
Hematology · University of Rochester Cancer Center
Answered on
Based on no personal experience, the literature suggests that daratumumab might be a reasonable second or third-line agent for autoimmune cytopenias.
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