How would you treat an elderly patient with metastatic breast cancer with two new progressive right breast/chest wall lesions?

I addressed the question of how to manage patients with symptomatic breast masses in a posting on December 19, 2025. The first question for this patient with progressive lesions is whether they are symptomatic now or not. If not currently symptomatic, then I would likely defer RT until such time as ...

This is a complicated situation, and my opinion varies based on the details. Broadly speaking, if the patient has a high level of competing risks of things that will limit their life expectancy (e.g., a high burden of metastatic disease, low KPS), then a short RT course to the local area of problema...

Adapted repeat quad shot RT (3 or more) to local-regional diseases in metastatic breast cancer showed rapid symptoms and tumor response as well as durable local-regional control without interrupting systemic therapy schedule.

Kil et al., PMID 40761685