What is your recommended dose and treatment volume for multifocal glioblastoma involving the bilateral cerebral hemispheres?

Median survival of multifocal/multicentric GBM is only about 5-10 months across series, and a recent study reported 2-year survival only 4% (PMID:22920963). Optimal radiation dose will depend on performance status, neurologic status, comorbidities, age, and social situation. Reasonable doses are:

- 0...