Topics:
Head and Neck Cancers • Radiation Oncology
What is your recommended way of managing a locally advanced bulky base of tongue (BOT) p16 negative squamous cell carcinoma extending into multiple structures of the supraglottic larynx?
Would you recommend concurrent chemoradiation (organ presrevation) vs. surgery (laryngectomy/pharyngectomy and extensive base of tongue resection) and adjuvant RT?
Answer from: Radiation Oncologist at Academic Institution
The only randomized study that I am aware of that compares upfront surgery followed by adjuvant RT with chemoRT for locally advanced squamous cell of the head and neck is the study by Iyer et al., PMID 25639864, and it showed comparable results in non-oral cavity or maxillary sinus sites, regardless...
Answer from: Radiation Oncologist at Academic Institution
Resection with free flap reconstruction performed by a surgeon experienced in microvascular surgery, preferably at a tertiary hospital, followed with RT or chemo-RT based on pathology.
Comments
Radiation Oncologist at University of Washington
Dr. @Avraham Eisbruch, I respect you and your opin...
Dr. @Avraham Eisbruch, I respect you and your opin...
Radiation Oncologist at University of Michigan
Dr. @Upendra Parvathaneni, my answer was influence...
Dr. @Upendra Parvathaneni, my answer was influence...
Radiation Oncologist at University of Washington
Thanks! Much appreciated.
Thanks! Much appreciated.
With upfront surgery, this patient's larynx cannot...