What is your surveillance regimen for children with nephroblastomatosis?

First, it is important to clarify that there are multiple forms of nephroblastomatosis and multiple clinical contexts in which surveillance for nephroblastomatosis may occur, and the medical literature has not always clearly defined discrete forms.

Nephroblastomatosis was originally defined as multiple/multifocal or diffuse nephrogenic rests (NR) (Beckwith et al., PMID 8383276); however, this definition is made challenging by the fact that the term nephrogenic rest is used to describe radiographic findings of renal lesions that do not clearly represent tumor, and to describe histopathologic findings on examination of nephrectomy specimens (Fialkowski et al., PMID 36545945). So a patient with multiple intralobar NR found at the time of nephre...